X-Chem First Biotech to Exceed 100 Billion Compounds in its Unique and Proprietary Small Molecule DNA-Encoded Library

WALTHAM, MA, USA – February 4, 2014 X-Chem, Inc., a privately held biotechnology company focused on applying its powerful product engine to the generation of novel small molecule therapeutics, today announced that the company has created the first biotech-owned screening library of small molecules to ever surpass 100 billion compounds. Its size now far exceeds that of even the largest conventional small molecule screening libraries by 10,000-fold, and its diversity is unprecedented. The library was created using the company’s cutting-edge and proprietary DNA-encoded platform. As described in a recent publication authored by X-Chem scientists (Litovchick A., Clark M. & A. Keefe (2014): “Universal Strategies for the DNAEncoding of Libraries of Small Molecules Using the Chemical Ligation of Oligonucleotide Tags.” Artificial DNA: PNA & XNA, vol 5, in press) a key advancement is a library synthesis process that enables the addition of a DNA tag using chemical methods.